VWF & Propeptide Assay

For the quantitative detection of von Willebrand Factor (VWF) and VWF Propeptide in human plasma and the calculation of a propeptide:VWF ratio

Von Willebrand Factor (VWF) is a multimeric, high molecular weight protein present in plasma that plays a pivotal role in successful recruitment and activation of platelets at the site of vascular injury. In addition, VWF serves as a carrier protein for the clotting factor, Factor VIII, protecting the Factor VIII from degradation..

The VWF Propeptide is synthesized as part of a pro-VWF protein and is subsequently cleaved, stored and secreted in an equi-molar ratio with mature VWF. The level of VWF Propeptide in the circulation can be used as a marker of VWF synthesis. In individuals with low VWF synthesis, the propeptide level is similarly decreased yielding a propeptide:VWF ratio near 1.0. In individuals with normal levels of VWF synthesis and decreased survival of VWF in circulation, an increased Propeptide:VWF ration is observed. The quantitative VWF deficiency observed in Type 1 VWD can be caused by ineffective synthesis and storage or by a decrease in the half-life of the VWF in the circulation. Clinically, It is important to recognize this enhanced clearance phenotype because the increased clearance of VWF can reduce the efficacy of desmopressin treatment in these patients.

• Only commercially available kit for the measurement of VWF propeptide
• Also measures the VWF antigen level
• Quantitative
• Easy-to-use
• Cost-effective
• Up to 41 samples can be tested in duplicate in 90 minutes

For Research Use Only (US & Canada)
For In Vitro Diagnostic Use / CE Marked (Europe)